Computational Methods for Mass Spectrometry Proteomics~tqw~ darksiderg torrent download

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            Computational Methods for Mass Spectrometry Proteomics

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Proteomics is the study of the subsets of proteins present in different parts of 

an organism and how they change with time and varying conditions. Mass 

spectrometry is the leading technology used in proteomics, and the field relies 

heavily on bioinformatics to process and analyze the acquired data.   Since 

recent years have seen tremendous developments in instrumentation and 

proteomics-related bioinformatics, there is clearly a need for a solid 

introduction to the crossroads where proteomics and bioinformatics meet.



Computational Methods for Mass Spectrometry Proteomics describes the different 

instruments and methodologies used in proteomics in a unified manner. The 

authors put an emphasis on the computational methods for the different phases of 

a proteomics analysis, but the underlying principles in protein chemistry and 

instrument technology are also described. The book is illustrated by a number of 

figures and examples, and contains exercises for the reader. Written in an 

accessible yet rigorous style, it is a valuable reference for both 

informaticians and biologists.



Computational Methods for Mass Spectrometry Proteomics is suited for advanced 

undergraduate and graduate students of bioinformatics and molecular biology with 

an interest in proteomics. It also provides a good introduction and reference 

source for researchers new to proteomics, and for people who come into more 

peripheral contact with the field. 



Table Of Contents



Preface ix

Acknowledgements xi

1 Protein, proteome, and proteomics 1

2 Protein separation – 2D gel electrophoresis 31

3 Protein digestion 43

4 Peptide separation – HPLC 53

5 Fundamentals of mass spectrometry 67

6 Mass spectrometry – MALDI-TOF 81

7 Protein identification and characterization by MS 97

8 Tandem MS or MS/MS analysis 119

9 Fragmentation models 141

10 Identification and characterization by MS/MS 153

11 Spectral comparisons 159

12 Sequential comparison – de novo sequencing 179

13 Database searching for de novo sequences 193

14 Large-scale proteomics 211

15 Quantitative MS-based proteomics 229

16 Peptides to proteins 243

17 Top-down proteomics 249

18 Standards 255

Bibliography 265

Index 277



Product Details



    * ISBN: 0470512970

    * ISBN-13: 9780470512975

    * Format: Hardcover, 296pp

    * Publisher: Wiley, John & Sons, Incorporated

    * Pub. Date: February 2008



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